Aro Bio Therapeutics

Join the team at Aro Biotherapeutics creating breakthrough biotherapeutics based on Centyrin oligonucleotide conjugates. Centyrins are small protein domains based on the fibronectin domains of human Tenascin C that combine the affinity and specificity properties of antibodies with the stability and tissue penetration properties of small molecules. We have engineered Centyrins with an array of specificities for normal and immune cell receptors. By linking Centyrin domains together genetically, we have created multi-specific binders that retain a small footprint to enable excellent tissue penetration. Engineered for high stability, multi-specific Centyrins are readily expressed and purified from E. coli or mammalian cells.

We are developing a platform for delivery of an array of intracellularly active payloads with a focus on oligonucleotides. Our team has built a strong set of in vitro and in vivo data validating the utility of Centyrins for receptor specific uptake in a variety of cell types. Centyrin conjugate mediated delivery provides the foundation for access to a set of intracellular targets that have long been considered undruggable.

Aro is building a wholly owned portfolio of Centyrin oligonucleotide conjugates for genetic and autoimmune diseases and developing a partnered portfolio of Centyrin conjugates for payload delivery in a variety of disease areas. Led by an experienced and exceptional team, Aro is backed by an exceptional syndicate that supports our commitment to advancing drug candidates with the potential to improve patient’s lives and to building an ideal environment for scientific and leadership growth.

Position Description – Senior/Principal Investigator (Immunology)

This is an exciting opportunity to join the company and play a key role progressing the first Centyrin-siRNA drug candidate to the clinic for inflammatory and autoimmune diseases and expand the applications for Centyrin-oligonucleotide conjugates. The candidate will be responsible for establishing target pathway linkages to immune cells and disease.

Responsibilities

  • Serve as a subject matter expert and establish robust in vitro immune assays to assess and validate targets and drug candidates
  • Provide support as a key member of a cross functional team to bring a Centyrin siRNA conjugate to the clinic
  • Oversee the design and execution of in vitro pharmacology and genomics studies
  • Manage laboratory scientists
  • Regularly present work to internal project teams and R&D Leadership
  • Minimally 50% of hands on benchwork is required and on-site 80% of time
  • Drive innovation while prosecuting drug discovery programs
  • Comply with laboratory safety procedures and maintain compliant laboratory records of experiments
  • Author study reports necessary to support regulatory filings

Qualifications

  • PhD in biological sciences (in Immunology a plus), with 3+ years of experience in pharma or biotech. Position level will be dependent upon qualifications.
  • Understanding of the fundamentals of drug discovery and development
  • Design and execute innate and adaptive immune cell related experiments as part of a collaborative team with focus on proteomics and genomics read-outs.
  • Responsible for critical review of immunological experiments and partnering with other scientific team members to design experiments to address key issues in program. Understanding of complex flow cytometry results is desired.
  • Maintains a high level of scientific rigor including significant understanding of data analysis including qPCR, RNA seq analysis, reproducibility and reliability of experimental data
  • Demonstrated ability to work independently and effective partnership as required in a matrixed and highly collaborative team
  • Demonstrated management experience of junior scientists
  • Strong communication skills, both written and oral with an ability to organize and communicate complex data sets in a clear and concise manner in different forums.
  • Experience authoring peer-reviewed scientific publications and presenting at scientific conferences

Aro Biotherapeutics is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, gender identity/gender expression, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.

Aro Biotherapeutics offers a competitive benefits package including:

  • A variety of health insurance options at competitive rates
  • Flexible Spending Accounts
  • Paid Time off, including personal and vacation time
  • Company holidays
  • 401(k) with company match
  • Disability and Life Insurance
  • Commuter Benefits
  • Employee training and development opportunities
  • And more!