Aro Bio Therapeutics

Aro Biotherapeutics is pioneering the development of tissue-targeted genetic medicines with a platform based on a proprietary protein technology called Centyrins. The Company is developing a wholly owned pipeline of Centyrin-based therapeutic candidates and is working with industry partners to leverage Centyrins for tissue-specific targeting of therapeutics for a diverse set of diseases.

Aro Biotherapeutics is harnessing its Centyrin platform to develop therapies that change the course of treatment for the most devastating diseases. We are building a product pipeline that will focus on novel medicines that will enable targeted delivery of oligonucleotides - and potentially other drug payloads - to a number of different cell types. Our initial wholly owned internal Aro pipeline is focused on orphan genetic and immune mediated diseases. In addition, our partnered pipeline is addressing rare muscle disease and other intractable diseases.

Our strategy also includes building a partnered pipeline of new therapies by forming collaborations with industry leaders. Via external partnerships, we can combine Centyrins with a variety of different drug classes to enable effective targeting and delivery of diverse therapeutics.

Aro Biotherapeutics is seeking a scientifically focused clinical leader who can integrate into a fast-paced life sciences company developing oligonucleotide Centyrin conjugates for genetic and orphan diseases. The successful candidate will possess a strong background in early clinical development of biologic and/or nucleic acid therapeutics, as well as significant leadership experience working in matrixed multidisciplinary teams.

Reporting to the CMO, the Senior/Executive Director, Translational Medicine, will be responsible for developing strategies for first in human and early development, from protocol design through execution, monitoring and oversight of the clinical studies, and for analysis and reporting of data for regulatory filings. The FIH clinical trial will be conducted in genetic muscle disease, and the candidate will collaborate closely with Discovery and Clinical Pharmacology on the translational package. The candidate will work with the CMO on the identification of principal investigators for Aro’s clinical studies, and scientific/clinical KOLs to advise the Company on developing a new class of receptor targeted genetic medicines. In parallel the candidate will support the CMO in building or sourcing clinical capabilities via CROs. The candidate will contribute to defining the strategic direction for the company through active participation in portfolio planning, new target selection and in due diligence activities and partnerships. The candidate will also assist the CMO with strategies for outsourcing and building an in-house clinical/regulatory team over the next 12-24 months. The position requires enthusiasm, passion, flexibility, attention to detail and a desire to be a pivotal member of a dynamic team committed to creating a new class of transformative medicines for patients.


  • MD/PhD, MD or PhD/PharmD with a minimum of 5-8 years of experience in clinical development in a pharmaceutical or biotech company setting
  • Experience with designing and operationalizing early clinical trials, ideally with programs focused on neuromuscular diseases and/or immune mediated diseases
  • Experience and training required to integrate understanding of clinical disease, molecular and genetic mechanisms of disease to create biomarker and pharmacodynamic endpoints supporting efficacy and safety assessments in early clinical trials
  • An understanding of GCP and ICH requirements and experience with IND/CTA filings, correspondence and/or meetings with regulatory agencies
  • An innovator with track record in advancement of biologic and/or bioconjugate therapeutics with an ability to be creative and take a proactive approach to problem solving
  • The candidate should have experience building and leading teams with excellent managerial skills, experience in managing vendors and contract research organizations
  • The successful candidate will have strong interpersonal, written and communication skills
  • Good written and verbal communication skills appropriate for communicating complex programs to scientific and non-scientific audiences are essential.

Aro Biotherapeutics is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, gender identity/gender expression, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.

Aro Biotherapeutics offers a competitive benefits package including:

  • A variety of health insurance options at competitive rates
  • Flexible Spending Accounts
  • Paid Time off, including personal and vacation time
  • Company holidays
  • 401(k) with company match
  • Disability and Life Insurance
  • Commuter Benefits
  • Employee training and development opportunities
  • And more!