Aro Biotherapeutics has an opportunity for a Ph.D., Associate Director/Director in our new laboratory located in Philadelphia, PA. Centyrins are a unique protein drug platform ideally suited for tissue or cell delivery of multiple drug payloads including nucleic acid drugs. Centyrins, a single domain protein engineered to combine the binding properties of antibodies with the biophysical properties of small molecules, represent a new approach to addressing diseases of high unmet need with molecular targets that have previously been ‘undruggable.’ Aro Biotx was launched in January 2018 and has office and laboratory space in the Cambridge Innovation Center in Philadelphia.
Reporting to the Vice President of Discovery and Translational Research, the successful candidate will be a key contributor and help drive our efforts to discover and develop intracellular targeted nucleic acids including mRNA, siRNA, ASO, miRNA as therapeutics. The ideal candidate will be involved in many aspects of molecular design, development, testing, interpretation, and troubleshooting of nucleic acid conjugates. Responsibilities will include laboratory based work (~50% of time) and management of activities and lab personnel related to nucleic acid conjugate therapeutics. Much of the chemistry work will be outsourced which will require close oversight of external vendors. The work will require interactions with biologists and chemists in a highly collaborative environment. The initial focus will be in the oncology space with the potential to expand to other disease areas including immunological diseases. The ideal candidate will join of team of chemists and biologists developing Centyrins and Centyrin-conjugates to advance a portfolio of drug candidates in disease areas with high unmet need.
PhD in a Biology discipline with an understanding of nucleic acid chemistry is required. At least 7 years of research in an academic or industrial setting post Ph.D. Significant expertise in the area of nucleic acid chemistry and application to nucleic acid based therapeutics. A candidate who has moved a molecule from discovery to early clinical development would be a plus. Experience in working in a team environment and with external collaborators is required. Excellent written and oral communication skills are critical. Ideal candidates will be independent, collaborative and enthusiastic about contributing to a fast-growing team in a culture that rewards innovation.
Aro Biotherapeutics is an equal opportunity employer; all qualified applicants will be considered for employment without regard for any characteristic protected by law. Aro Biotherapeutics provides a competitive benefits package.