Scientist III/IV, Immunology

Join the team at Aro Biotherapeutics creating breakthrough biotherapeutics based on Centyrin oligonucleotide conjugates. Centyrins are small protein domains based on the fibronectin domains of human Tenascin C that combine the affinity and specificity properties of antibodies with the stability and tissue penetration properties of small molecules. We have engineered Centyrins with an array of specificities for normal and immune cell receptors. By linking Centyrin domains together genetically, we have created multi-specific binders that retain a small footprint to enable excellent tissue penetration. Engineered for high stability, multi-specific Centyrins are readily expressed and purified from E. coli or mammalian cells.

We are developing a platform for delivery of an array of intracellularly active payloads with a focus on oligonucleotides. Our team has built a strong set of in vitro and in vivo data validating the utility of Centyrins for receptor specific uptake in a variety of cell types. Centyrin conjugate mediated delivery provides the foundation for access to a set of intracellular targets that have long been considered undruggable.

Aro is building a wholly owned portfolio of Centyrin oligonucleotide conjugates for genetic and autoimmune diseases and developing a partnered portfolio of Centyrin conjugates for payload delivery in a variety of disease areas. Led by an experienced and exceptional team, Aro is backed by an exceptional syndicate that supports our commitment to advancing drug candidates with the potential to improve patient’s lives and to building an ideal environment for scientific and leadership growth.

Position Description – Associate Scientist III/IV, Immunology

The primary responsibility will be to actively engage in early discovery efforts by designing and executing experiments to support the Immunology discovery strategy. The candidate will independently execute experiments, analyze and record data, and communicate findings to the organization. This is a unique opportunity to learn, contribute, and demonstrate the potential of using Centyrins, a novel platform to deliver siRNA using the for the treatment of immunological diseases.

Please note this is a 100% bench/on-site position

Responsibilities

• Independently design and execute experiments for in vitro and ex vivo studies to contribute to research goals
• Independently analyze and record data in electronic notebook
• Communicate experimental plans and data to direct team and multiple cross-functional scientific teams
• Proactively collaborate across various functions to advance discovery programs.
• Train junior staff and co-ops as necessary

Qualifications

• A minimum of bachelor’s degree is required, advanced Master’s Degree is preferred, in Immunology, biology, pharmacology, or related discipline
• Prior experience from pharma or biotech is desired.
• Knowledge of primary human cell isolation techniques from whole blood, expertise in primary immune cell culture and co-culture assays
• Expertise performing various immunological assays using small molecule or biologicals.
• Experience in various downstream read-outs and analysis using multiplex ELISAs, qPCR, histology and multi color flow cytometry.
• Experience with ex vivo mouse and cyno immunological assays is a plus.
• Familiarity with GraphPad Prism or similar statistical software preferred
• Detail-oriented, self-motivated, and comfortable working with highly technical projects in a dynamic environment
• Highly adaptable and responsive to delivering on fast-paced projects
• Effective written and oral communication skills
• Team-oriented with a strong work ethic

Aro Biotherapeutics is an equal opportunity employer that is committed to diversity and inclusion in the workplace. We prohibit discrimination and harassment of any kind based on race, color, sex, religion, sexual orientation, gender identity/gender expression, national origin, disability, genetic information, pregnancy, or any other protected characteristic as outlined by federal, state, or local laws.

Aro Biotherapeutics offers a competitive benefits package including:

• A variety of health insurance options at competitive rates
• Flexible Spending Accounts
• Paid Time off, including personal and vacation time
• Company holidays
• 401(k) with company match
• Disability and Life Insurance
• Commuter Benefits
• Employee training and development opportunities
• And more!